Invitro Activity and Docking Approach In Silico Leaf Extract Syzygium polyanthum (Wight) Walp. as a Salmonella typhi Inhibitor

Indonesian people had long used plants as traditional medicine. In addition to maintaining health, medicine was in great demand and prevents disease. We often encounter syzygium polyanthum leaves a complement tamarind pepes, which were believed act preservative. This study aimed determine qualitatively bay leaf extract an antimicrobial, Salmonella typhi. Methanol extraction of polyantum would be partitioned with hexane ethyl acetate solvents. The anti-microbial potential shown the Maximum Inhibitory Concentration (MIC) test, identification compound using GC-MS its antibacterial by docking molecule silico technique against 5L3J protein. MIC results that partition at 100 ppm 22.09 mm inhibition 80 ppm, 18.15 inhibition. GC-MS’ testing resulted polianthum showed presence alpha-pinene, alpha-cubenene, 1H-Cyclopropa [a] naphthalene, nerolidol, humulene epoxide II, phytol, 9,12,15-Octadecatrien-1-ol, Squalene, Alpha-tocopherol, Beta-sitosterol, azulene, valence, Azulene beta-Panasinen. However, lowest binding affinity value obtained from cytosterol −9.45 kcal/mol Valencene solutions −6.93 n-hexane solvent. While positive control-Chloramphenicol −36.93 kcal/mol. means could alternative for typhoid.
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